Submit a complete CV along with the names of 3 references via E-mail to: Deepak Nagrath, dnagrath at umich dot edu
Job Summary
Postdoctoral Positions in Cancer Metabolism, Tumor microenvironment, and Immunometabolism
The Nagrath laboratory at the University of Michigan aims to broaden their work on understanding the role of tumor microenvironment in regulation of cancer metabolism and translate the findings into novel therapeutic approaches. We are working to uncover the metabolic interactions between cancer cells and cells in neighboring tissue that support cancer growth and metastasis.
Postdoctoral positions are immediately available to outstanding candidates. The Nagrath laboratory focuses on innovative research in cancer metabolism with a specific focus on tumor metabolism, tumor microenvironment, extracellular vesicles, and immunometabolism.
Our recent publications:
Tumor microenvironment and cancer metabolism: (Yang et al., 2016, Cell Metabolism)
Exosomes, tumor microenvironment, cancer metabolism: (Zhao et al., 2016, eLife)
Oncogenes and cancer metabolism: (Dey et al., Nature, 2017; Han et al., Nature Communications, 2017, Zand et al., JNCI, 2016)
Current projects are focused on two broad areas:
1. Developing Metabolic Therapies for Targeting Tumor Microenvironment: Our lab has discovered that stromal cells supply essential metabolites to cancer cells by recycling metabolites secreted by cancer cells. We have now taken on the challenge of identifying such metabolic interactions between stromal and cancer cells that can be targeted by drugs to improve therapeutic outcomes for cancer
2. Dissecting Metabolic Influences of Tumor Microenvironment: Our lab discovered that tumor microenvironment derived exosomes act as care packages sent out by stromal cells to supply amino acids to nutrient-deprived cancer cells. We are now working to unravel how extracellular vesicles from different parts of the TME can support cancer cell metabolism, with a goal of targeting this important mode of communication
The University of Michigan Medical School and Biomedical Engineering Department consistently rank among the top 10 programs in the United States, according to US News & World Report. The scientific environment at U of M is ideally suited for the research pursued in the Nagrath lab. The strengths of the Nagrath laboratory, coupled with the facilities and equipment at U of M provides an exciting and exceptional scientific environment that is fully supportive of the proposed research.
Required Qualifications*
We seek outstanding candidates with a strong background in cancer biology or immunology. Candidates with experience in fields of biochemistry, extracellular vesicles trafficking, cancer metabolism, or animal models in cancer are preferred.
Additional Information
Michigan Engineering’s vision is to be the world’s preeminent college of engineering serving the common good. This global outlook, leadership focus and service commitment permeate our culture. Our vision is supported by a mission and values that, together, provide the framework for all that we do. Information about our vision, mission and values can be found at: http://strategicvision.engin.umich.edu/
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Background Screening
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Application Deadline
Job openings are posted for a minimum of seven calendar days. This job may be removed from posting boards and filled anytime after the minimum posting period has ended.
U-M EEO/AA Statement
The University of Michigan is an equal opportunity/affirmative action employer.